Wetenschappelijke artikelen

De Universitaire Stichting kan subsidies verlenen om het publiceren te bevorderen van wetenschappelijke artikelen in internationaal gereviewde tijdschriften. De subsidie kan enkel toegekend worden aan werken die aantoonbaar voortkomen uit onderzoek in een Belgische onderzoekseenheid. 

OPGELET:   De aanvragen voor het subsidiëren van de kosten voor het publiceren van wetenschappelijke artikelen dienen te worden ingediend door middel van een "online" systeem. Dit systeem zal zowel voor de aanvragers als voor de administratie van de Universitaire Stichting het werk vergemakkelijken. 

Klik deze link naar het indiensysteem, waar het reglement, een beschrijving van de te volgen procedure en de online indienformulieren beschikbaar zijn. 

Opmerkingen over het online systeem, correcties en gewenste aanpassingen zijn welkom. Gelieve deze te zenden aan fu.us@universityfoundation.be.

Wetenschappelijke artikelen gesubsidieerd door de Universitaire Stichting

Wat volgt is een lijst van wetenschappelijke artikelen waaraan recent subsidie werd toegekend door de Universitaire Stichting. De artikelen zijn gesorteerd op jaar van uitgave en per titel.

Kevin Van Sundert et al.

Van Sundert, K. et  al. (2018) The influence of soil properties and nutrients on conifer forest growth in Sweden, and the first steps in developing a nutrient availability metric.  Biogeosciences, 15, 3475–3496, 2018, https://doi.org/10.5194/bg-15-3475-2018.

The availability of nutrients is one of the factors that regulate terrestrial carbon cycling and modify ecosystem responses to environmental changes. Nonetheless, nutrient availability is often overlooked in climate–carbon cycle studies because it depends on the interplay of various soil factors that would ideally be comprised into metrics applicable at large spatial scales. Such metrics do not currently exist.

Susan DIERICKX et al.

Dierickx S. et al. (2018) ‘I am always crying on the inside’: a qualitative study on the implications of infertility on women’s lives in urban Gambia. Reproductive Health 15:151, https://doi.org/10.1186/s12978-018-0596-2

Background: There is an increasing awareness that infertility in Sub-Saharan Africa constitutes a severe social and public health problem. Few of the existing studies on infertility explicitly take into account the differences between women. However, how women experience infertility is formed by their various social positions. This research explores the implications of infertility on women’s lives in urban Gambia and aims to provide an in-depth understanding of how this relates to gender and cultural norms as well as different social positions.
Alen Tosenberger, Didier Gonze, Sylvain Bessonnard, Michel Cohen-Tannoudji, Claire Chazaud & Geneviève Dupont

Tosenberger, A. et al.  (2017) A multiscale model of early cell lineage specification including cell division, npj Systems Biology and Applications (2017) 3:16 ; doi:10.1038/s41540-017-0017-0.

Embryonic development is a self-organised process during which cells divide, interact, change fate according to a complex gene regulatory network and organise themselves in a three-dimensional space. Here, we model this complex dynamic phenomenon in the context of the acquisition of epiblast and primitive endoderm identities within the inner cell mass of the preimplantation embryo in the mouse. The multiscale model describes cell division and interactions between cells, as well as biochemical reactions inside each individual cell and in the extracellular matrix.

Isabelle Houbracken & Luc Bouwens

Houbracken, I. and Bouwens, L. (2017) Acinar cells in the neonatal pancreas grow by self-duplication and not by neogenesis from duct cellsScientific Reports 7, Article number: 12643. doi:10.1038/s41598-017-12721-9.

Pancreatic acinar cells secrete digestive enzymes necessary for nutrient digestion in the intestine. They are considered the initiating cell type of pancreatic cancer and are endowed with differentiation plasticity that has been harnessed to regenerate endocrine beta cells. However, there is still uncertainty about the mechanisms of acinar cell formation during the dynamic period of early postnatal development.

Joery GOOSSENS et al.

Goossens, J. et al (2017) EEG dominant frequency peak differentiates between Alzheimer’s disease and frontotemporal lobar degeneration. Journal of Alzheimer’s Disease vol. 55 pp. 53-58.

We investigated the power of EEG as biomarker in differential diagnosis of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD). EEG was recorded from 106 patients with AD or FTLD, of which 37 had a definite diagnosis, and 40 controls. Dominant frequency peaks were extracted for all 19 channels, for each subject. The average frequency of the largest dominant frequency peaks (maxpeak) was significantly lower in AD than FTLD patients and controls. Based on ROC analysis, classification could be made with diagnostic accuracy of 78.9%.

Anne Fromont et al.

Fromont, A. et al.  (2017) Exploring the validity of scores from the Rosenberg Self-Esteem Scale (RSES) in Burundi: A multi-strategy approach.  Journal of Psychology in Africa, Vol. 27, no.4, pp. 316-324.

The present study aimed to validate the Rosenberg Self-Esteem Scale (RSES) in Burundi, through a multi-strategy approach used in cross-cultural studies. Respondents were 906 health workers (men =56%; caregivers 60%). They responded to a bilingual version of RSES. We utilized Confirmatory Factorial Analysis (CFA) with structural equation modelling and a back translation test to explore the structure of the RSES and the reliability of scores from the scale.

Sabine Rudischhauser

Rudischhauser, S. (2017) From the 8-Hour Day to the 40-Hour Week: Legitimization Discourses of Labour Legislation between the Wars in France and Belgium. Politics and Governance, Volume 5, Issue 1, Pages 6–14.

In the interwar period both France and Belgium passed legislation reducing the number of working hours and established a hybrid regulatory regime lending a certain degree of official authority to collective agreements. The paper analyses discourses by scholars who, as experts, were close to the political elites, and who tried to legitimize this kind of co-regulation by pointing out the inefficiency of state intervention and the epistemic authority of non-state actors.

Jonas R.M. Van Audenaerde et al.

Van Audenaerde, JRM et al. (2017) Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells.  Oncotarget.

Pancreatic ductal adenocarcinoma (PDAC) is the 4th leading cause of cancerrelated death in Western countries with a 5-year survival rate below 5%. One of the hallmarks of this cancer is the strong desmoplastic reaction within the tumor microenvironment (TME), orchestrated by activated pancreatic stellate cells (PSC). This results in a functional and mechanical shield which causes resistance to conventional therapies.

Lorenz Demey & Hans Smessaert

Demey, L & Smessaert, H. Logical and Geometrical Distance in Polyhedral Aristotelian Diagrams in Knowledge Representation. Symmetry 20179(10), 204.

Aristotelian diagrams visualize the logical relations among a finite set of objects. These diagrams originated in philosophy, but recently, they have also been used extensively in artificial intelligence, in order to study (connections between) various knowledge representation formalisms. In this paper, we develop the idea that Aristotelian diagrams can be fruitfully studied as geometrical entities. In particular, we focus on four polyhedral Aristotelian diagrams for the Boolean algebra B4, viz.

Didier Gonze, Leo Lahti, Jeroen Raes & Karoline Faust

Gonze, D. et al. (2017) Multi-stability and the origin of microbial community types.  The ISME Journal (doi:10.1038/ismej.2017.60)

The study of host-associated microbial community composition has suggested the presence of alternative community types. We discuss three mechanisms that could explain these observations. The most commonly invoked mechanism links community types to a response to environmental change; alternatively, community types were shown to emerge from interactions between members of local communities sampled from a metacommunity. Here, we emphasize multi-stability as a third mechanism, giving rise to different community types in the same environmental conditions.

Joery Goossens et al.

Goossens, J. et al. (2017) No added diagnostic value of nonphosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis. Alzheimer's Research & Therapy 9:49

Background: The Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers Aβ1–42, t-tau, and p-tau181 overlap with other diseases. New tau modifications or epitopes, such as the non-phosphorylated tau fraction (p-taurel), may improve differential dementia diagnosis. The goal of this study is to investigate if p-taurel can improve the diagnostic performance of the AD CSF biomarker panel for differential dementia diagnosis. 

Robert Hilbrands et al.

Hilbrands, R. et al. (2017) Pancreas and gallbladder agenesis in a newborn with semilobar holoprosencephaly, a case report. BMC Medical Genetics,  DOI 10.1186/s12881-017-0419-2.

Background: Pancreatic agenesis is an extremely rare cause of neonatal diabetes mellitus and has enabled the discovery of several key transcription factors essential for normal pancreas and beta cell development. 

Julie Jacobs at al.

Jacobs, J. at al. (2017) Preclinical data on the combination of cisplatin and anti-CD70 therapy in non-small cell lung cancer as an excellent match in the era of combination therapy. Oncotarget.

In contrast to the negligible expression of the immunomodulating protein CD70 in normal tissue, we have demonstrated constitutive overexpression of CD70 on tumor cells in a subset of primary non-small cell lung cancer (NSCLC) biopsies. This can be exploited by CD70-targeting antibody-dependent cellular cytotoxicity (ADCC)-inducing antibodies. Early clinical trials of these antibodies have already shown promising results in CD70-positive malignancies. In this study, we explored the potential of cisplatin to induce CD70 expression in NSCLC.

Kobe Desender, Filip Van Opstal & Eva Van den Bussche

Desender, K. et al.  (2017) Subjective experience of difficulty depends on multiple cues. Sci. Rep. 7, 44222; doi: 10.1038/srep44222.

Human cognition is characterized by subjective experiences that go along with our actions, but the nature and stability of these experiences remain largely unclear. In the current report, the subjective experience of difficulty is studied and it is proposed that this experience is constructed by integrating information from multiple cues.

Marina Miscioscia, Adelaide Blavier, Paolo R. Pagone and Alessandra Simonelli

Miscioscia M et al.  (2017) The Desire of Parenthood: Intuitive Co-parental Behaviors and Quality of Couple Relationship among Italian and Belgian Same-Sex and Opposite-Sex CouplesFront. Psychol. 8:110. doi: 10.3389/fpsyg.2017.00110

Studies that focused on family issues have allowed a great understanding of the aspects related to its subsystems, such as parenting desire and its expectations, couples’ satisfaction and quality of child’s outcomes. All these aspects are greatly interconnected and contribute to the creation of specific family dynamics, such as the quality of family interactions. The present study focuses on intuitive co-parental behaviors and the quality of couple relationship observed during the decision process (intention and desire) to be (or become) parents.

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